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TitleMDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models.
Journal, issue, pagesCancer Res., Vol. 73, Page 2587-2597, Year 2013
Publish dateJan 9, 2013 (structure data deposition date)
AuthorsTovar, C. / Graves, B. / Packman, K. / Filipovic, Z. / Xia, B.H. / Tardell, C. / Garrido, R. / Lee, E. / Kolinsky, K. / To, K.H. ...Tovar, C. / Graves, B. / Packman, K. / Filipovic, Z. / Xia, B.H. / Tardell, C. / Garrido, R. / Lee, E. / Kolinsky, K. / To, K.H. / Linn, M. / Podlaski, F. / Wovkulich, P. / Vu, B. / Vassilev, L.T.
External linksCancer Res. / PubMed:23400593
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-4ipf:
The 1.7A crystal structure of humanized Xenopus MDM2 with RO5045337
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-1F0:
[(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • xenopus laevis (African clawed frog)
KeywordsLIGASE/ANTAGONIST / MDM2 / P53 / PROTEIN-PROTEIN INTERACTION / IMIDAZOLINE / E3 UBIQUITIN LIGASE / NUCLEUS / LIGASE-ANTAGONIST complex

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