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TitleBax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 152, Page 519-, Year 2013
Publish dateOct 4, 2012 (structure data deposition date)
AuthorsCzabotar, P.E. / Westphal, D. / Dewson, G. / Ma, S. / Hockings, C. / Fairlie, W.D. / Lee, E.F. / Yao, S. / Robin, A.Y. / Smith, B.J. ...Czabotar, P.E. / Westphal, D. / Dewson, G. / Ma, S. / Hockings, C. / Fairlie, W.D. / Lee, E.F. / Yao, S. / Robin, A.Y. / Smith, B.J. / Huang, D.C. / Kluck, R.M. / Adams, J.M. / Colman, P.M.
External linksCell(Cambridge,Mass. ) / PubMed:23374347
MethodsX-ray diffraction
Resolution2.206 - 2.998 Å
Structure data

PDB-4bd2:
Bax domain swapped dimer in complex with BidBH3
Method: X-RAY DIFFRACTION / Resolution: 2.206 Å

PDB-4bd6:
Bax domain swapped dimer in complex with BaxBH3
Method: X-RAY DIFFRACTION / Resolution: 2.494 Å

PDB-4bd7:
Bax domain swapped dimer induced by octylmaltoside
Method: X-RAY DIFFRACTION / Resolution: 2.801 Å

PDB-4bd8:
Bax domain swapped dimer induced by BimBH3 with CHAPS
Method: X-RAY DIFFRACTION / Resolution: 2.22 Å

PDB-4bdu:
Bax BH3-in-Groove dimer (GFP)
Method: X-RAY DIFFRACTION / Resolution: 2.998 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PR:
PRASEODYMIUM ION

ChemComp-CL:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
  • aequorea victoria (jellyfish)
KeywordsAPOPTOSIS / PROGRAMMED CELL DEATH / BCL-2 FAMILY. / BCL-2 FAMILY / CHIMERA

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