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Structure paper

TitleEngineering allosteric control to an unregulated enzyme by transfer of a regulatory domain
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 2111-2116, Year 2013
Publish dateAug 26, 2012 (structure data deposition date)
AuthorsCross, P.J. / Allison, T.M. / Dobson, R.C.J. / Jameson, G.B. / Parker, E.J.
External linksProc. Natl. Acad. Sci. USA / PubMed:23345433
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-4grs:
Crystal structure of a chimeric DAH7PS
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-TYR:
TYROSINE

ChemComp-HOH:
WATER

Source
  • thermotoga maritima (bacteria)
  • pyrococcus furiosus (archaea)
KeywordsTRANSFERASE / DAHP / DAHPS / DAH7PS / TIM BARREL / ACT DOMAIN / ALLOSTERIC REGULATION / AROMATIC BIOSYNTHESIS / SHIKIMATE PATHWAY / TRANSFERABLE ALLOSTERY

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