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TitleDiscovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 979-984, Year 2013
Publish dateDec 11, 2012 (structure data deposition date)
AuthorsJin, M. / Wang, J. / Kleinberg, A. / Kadalbajoo, M. / Siu, K.W. / Cooke, A. / Bittner, M.A. / Yao, Y. / Thelemann, A. / Ji, Q. ...Jin, M. / Wang, J. / Kleinberg, A. / Kadalbajoo, M. / Siu, K.W. / Cooke, A. / Bittner, M.A. / Yao, Y. / Thelemann, A. / Ji, Q. / Bhagwat, S. / Mulvihill, K.M. / Rechka, J.A. / Pachter, J.A. / Crew, A.P. / Epstein, D. / Mulvihill, M.J.
External linksBioorg. Med. Chem. Lett. / PubMed:23317569
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-4id7:
ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-1G0:
cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex

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