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TitleInsights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 431, Page 232-238, Year 2013
Publish dateMay 1, 2012 (structure data deposition date)
AuthorsLiu, Z. / Yedidi, R.S. / Wang, Y. / Dewdney, T.G. / Reiter, S.J. / Brunzelle, J.S. / Kovari, I.A. / Kovari, L.C.
External linksBiochem. Biophys. Res. Commun. / PubMed:23313846
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-4eyr:
Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-RIT:
RITONAVIR / medication, antiretroviral*YM

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE/HYDROLASE INHIBITOR / Protease / HYDROLASE-HYDROLASE INHIBITOR complex

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