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Structure paper

TitleSubstrate selectivity analyses of factor inhibiting hypoxia-inducible factor.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 52, Page 1700-1704, Year 2013
Publish dateAug 17, 2012 (structure data deposition date)
AuthorsYang, M. / Hardy, A.P. / Chowdhury, R. / Loik, N.D. / Scotti, J.S. / McCullagh, J.S. / Claridge, T.D. / McDonough, M.A. / Ge, W. / Schofield, C.J.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:23296631
MethodsX-ray diffraction
Resolution2.39 - 2.5 Å
Structure data

PDB-4b7e:
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CONSENSUS ANKYRIN REPEAT DOMAIN-LEU PEPTIDE (20-MER)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-4b7k:
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CONSENSUS ANKYRIN REPEAT DOMAIN-SER PEPTIDE (20-MER)
Method: X-RAY DIFFRACTION / Resolution: 2.39 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsOXIDOREDUCTASE/PEPTIDE / OXIDOREDUCTASE-PEPTIDE COMPLEX / OXIDOREDUCTASE / NON-HEME / IRON / 2-OXOGLUTARATE / DIOXYGENASE / OXYGENASE / DNA-BINDING / METAL-BINDING / TRANSCRIPTION / HELIX-LOOP-HELIX-BETA / DSBH / FACIAL TRIAD / ASPARAGINYL/ ASPARTYL HYDROXYLASE / TRANSCRIPTION AND EPIGENETIC REGULATION / SIGNALING / ARD / BETA-HYDROXYLATION / TRANSCRIPTION ACTIVATOR/INHIBITOR / HYPOXIA / HELIX-LOOP-TRANSCRIPTION / HELIX-BETA / DEVELOPMENT / ANKYRIN REPEAT DOMAIN

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