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-Structure paper
タイトル | LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. |
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ジャーナル・号・ページ | Invest New Drugs, Vol. 31, Page 833-844, Year 2013 |
掲載日 | 2012年3月28日 (構造データの登録日) |
![]() | Yan, S.B. / Peek, V.L. / Ajamie, R. / Buchanan, S.G. / Graff, J.R. / Heidler, S.A. / Hui, Y.H. / Huss, K.L. / Konicek, B.W. / Manro, J.R. ...Yan, S.B. / Peek, V.L. / Ajamie, R. / Buchanan, S.G. / Graff, J.R. / Heidler, S.A. / Hui, Y.H. / Huss, K.L. / Konicek, B.W. / Manro, J.R. / Shih, C. / Stewart, J.A. / Stewart, T.R. / Stout, S.L. / Uhlik, M.T. / Um, S.L. / Wang, Y. / Wu, W. / Yan, L. / Yang, W.J. / Zhong, B. / Walgren, R.A. |
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手法 | X線回折 |
解像度 | 1.8 Å |
構造データ | ![]() PDB-4eev: |
化合物 | ![]() ChemComp-L1X: ![]() ChemComp-HOH: |
由来 |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / protein tyrosine kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex |