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Title | LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. |
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Journal, issue, pages | Invest New Drugs, Vol. 31, Page 833-844, Year 2013 |
Publish date | Mar 28, 2012 (structure data deposition date) |
Authors | Yan, S.B. / Peek, V.L. / Ajamie, R. / Buchanan, S.G. / Graff, J.R. / Heidler, S.A. / Hui, Y.H. / Huss, K.L. / Konicek, B.W. / Manro, J.R. ...Yan, S.B. / Peek, V.L. / Ajamie, R. / Buchanan, S.G. / Graff, J.R. / Heidler, S.A. / Hui, Y.H. / Huss, K.L. / Konicek, B.W. / Manro, J.R. / Shih, C. / Stewart, J.A. / Stewart, T.R. / Stout, S.L. / Uhlik, M.T. / Um, S.L. / Wang, Y. / Wu, W. / Yan, L. / Yang, W.J. / Zhong, B. / Walgren, R.A. |
External links | Invest New Drugs / PubMed:23275061 |
Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | PDB-4eev: |
Chemicals | ChemComp-L1X: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / protein tyrosine kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex |