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Structure paper

TitleIdentification of SERPINB1 as a physiological inhibitor of human granzyme H
Journal, issue, pagesJ. Immunol., Vol. 190, Page 1319-1330, Year 2013
Publish dateJul 25, 2012 (structure data deposition date)
AuthorsWang, L. / Li, Q. / Wu, L. / Liu, S. / Zhang, Y. / Yang, X. / Zhu, P. / Zhang, H. / Zhang, K. / Lou, J. ...Wang, L. / Li, Q. / Wu, L. / Liu, S. / Zhang, Y. / Yang, X. / Zhu, P. / Zhang, H. / Zhang, K. / Lou, J. / Liu, P. / Tong, L. / Sun, F. / Fan, Z.
External linksJ. Immunol. / PubMed:23269243
MethodsX-ray diffraction
Resolution2.9 - 3 Å
Structure data

PDB-4ga7:
Crystal structure of human serpinB1 mutant
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-4gaw:
Crystal structure of active human granzyme H
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsHYDROLASE INHIBITOR / serpin / Conformational change / serine protease inhibitor / Cathepsin G inhibitor / chymase inhibitor / chymotrypsin inhibitor / HYDROLASE / serine protease / Cytolysis / cytotoxic granules

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