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Structure paper

TitleDNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion.
Journal, issue, pagesNucleic Acids Res., Vol. 41, Page 1848-1858, Year 2013
Publish dateSep 4, 2012 (structure data deposition date)
AuthorsFreudenthal, B.D. / Beard, W.A. / Wilson, S.H.
External linksNucleic Acids Res. / PubMed:23267011
MethodsX-ray diffraction
Resolution1.949 - 2.2 Å
Structure data

PDB-4gxi:
R283K DNA polymerase beta binary complex with a templating 8OG
Method: X-RAY DIFFRACTION / Resolution: 1.949 Å

PDB-4gxj:
R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dCTP analog
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4gxk:
R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dATP analog
Method: X-RAY DIFFRACTION / Resolution: 1.998 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-6CF:
2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine

ChemComp-MN:
Unknown entry

ChemComp-F2A:
2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / Transferase / lyase/DNA polymerase / TRANSFERASE-DNA complex

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