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TitleLead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 23, Page 728-732, Year 2013
Publish dateOct 16, 2012 (structure data deposition date)
AuthorsMiyazaki, M. / Naito, H. / Sugimoto, Y. / Kawato, H. / Okayama, T. / Shimizu, H. / Kitagawa, M. / Seki, T. / Fukutake, S. / Aonuma, M. / Soga, T.
External linksBioorg. Med. Chem. Lett. / PubMed:23266121
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-3vzv:
Crystal structure of human mdm2 with a dihydroimidazothiazole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-VZV:
1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-6-methyl-3-(propan-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N,N-dimethyl-L-prolinamide

Source
  • homo sapiens (human)
KeywordsLIGASE/LIGASE INHIBITOR / Ubiquitin-protein ligase E3 Mdm2 / p53 / LIGASE-LIGASE INHIBITOR complex

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