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-Structure paper
Title | Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 23, Page 897-901, Year 2013 |
Publish date | Oct 16, 2012 (structure data deposition date) |
![]() | Staben, S.T. / Blaquiere, N. / Tsui, V. / Kolesnikov, A. / Do, S. / Bradley, E.K. / Dotson, J. / Goldsmith, R. / Heffron, T.P. / Lesnick, J. ...Staben, S.T. / Blaquiere, N. / Tsui, V. / Kolesnikov, A. / Do, S. / Bradley, E.K. / Dotson, J. / Goldsmith, R. / Heffron, T.P. / Lesnick, J. / Lewis, C. / Murray, J. / Nonomiya, J. / Olivero, A.G. / Pang, J. / Rouge, L. / Salphati, L. / Wei, B. / Wiesmann, C. / Wu, P. |
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Methods | X-ray diffraction |
Resolution | 2.78 Å |
Structure data | ![]() PDB-4hle: |
Chemicals | ![]() ChemComp-17V: |
Source |
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![]() | Transferase/Transferase Inhibitor / lipid kinase / kinase / Transferase-Transferase Inhibitor complex |