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Structure paper

TitleATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Journal, issue, pagesNature, Vol. 494, Page 121-124, Year 2012
Publish dateNov 6, 2012 (structure data deposition date)
AuthorsZhou, H. / Sun, L. / Yang, X.L. / Schimmel, P.
External linksNature / PubMed:23263184
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4hvc:
Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-HFG:
7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one / alkaloid, medication*YM

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordsligase/ligase inhibitor / ligase / ligase-ligase inhibitor complex

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