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-Structure paper
Title | Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 15-30, Year 2013 |
Publish date | Nov 7, 2012 (structure data deposition date) |
![]() | Friberg, A. / Vigil, D. / Zhao, B. / Daniels, R.N. / Burke, J.P. / Garcia-Barrantes, P.M. / Camper, D. / Chauder, B.A. / Lee, T. / Olejniczak, E.T. / Fesik, S.W. |
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Methods | X-ray diffraction |
Resolution | 1.53 - 2.8 Å |
Structure data | ![]() PDB-4hw2: ![]() PDB-4hw3: ![]() PDB-4hw4: |
Chemicals | ![]() ChemComp-19H: ![]() ChemComp-PGE: ![]() ChemComp-EDO: ![]() ChemComp-19G: ![]() ChemComp-HOH: |
Source |
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![]() | APOPTOSIS/INHIBITOR / regulation of apoptosis / maintenance of viability / APOPTOSIS / APOPTOSIS-INHIBITOR complex / Anti-apoptotic protein / BH3 peptides |