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-Structure paper
Title | Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. |
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Journal, issue, pages | Plos One, Vol. 7, Page e50864-e50864, Year 2012 |
Publish date | Nov 5, 2012 (structure data deposition date) |
Authors | Heise, C.E. / Murray, J. / Augustyn, K.E. / Bravo, B. / Chugha, P. / Cohen, F. / Giannetti, A.M. / Gibbons, P. / Hannoush, R.N. / Hearn, B.R. ...Heise, C.E. / Murray, J. / Augustyn, K.E. / Bravo, B. / Chugha, P. / Cohen, F. / Giannetti, A.M. / Gibbons, P. / Hannoush, R.N. / Hearn, B.R. / Jaishankar, P. / Ly, C.Q. / Shah, K. / Stanger, K. / Steffek, M. / Tang, Y. / Zhao, X. / Lewcock, J.W. / Renslo, A.R. / Flygare, J. / Arkin, M.R. |
External links | Plos One / PubMed:23227217 |
Methods | X-ray diffraction |
Resolution | 2.074 Å |
Structure data | PDB-4hva: |
Chemicals | ChemComp-4HV: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / Caspase-6 / active / VEID / uncompetitive inhibition / ternary complex / Caspase / protease / HYDROLASE-HYDROLASE INHIBITOR complex |