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-Structure paper
Title | A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. |
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Journal, issue, pages | Retrovirology, Vol. 9, Page 99-99, Year 2012 |
Publish date | Nov 22, 2012 (structure data deposition date) |
Authors | Johnson, B.C. / Pauly, G.T. / Rai, G. / Patel, D. / Bauman, J.D. / Baker, H.L. / Das, K. / Schneider, J.P. / Maloney, D.J. / Arnold, E. ...Johnson, B.C. / Pauly, G.T. / Rai, G. / Patel, D. / Bauman, J.D. / Baker, H.L. / Das, K. / Schneider, J.P. / Maloney, D.J. / Arnold, E. / Thomas, C.J. / Hughes, S.H. |
External links | Retrovirology / PubMed:23217210 |
Methods | X-ray diffraction |
Resolution | 2.2964 - 2.7004 Å |
Structure data | PDB-4i2p: PDB-4i2q: |
Chemicals | ChemComp-G73: ChemComp-HOH: ChemComp-1BT: ChemComp-EDO: |
Source |
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Keywords | HYDROLASE / TRANSFERASE/INHIBITOR / P51/P66 / hetero dimer / NNRTI / nonnucleoside inhibitor / AIDS / HIV / DNA recombination / RNA-directed DNA polymerase / DNA polymerase / endonuclease / multifunctional enzyme / transferase / TRANSFERASE-INHIBITOR complex |