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TitleIdentification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.
Journal, issue, pagesDiabetologia, Vol. 56, Page 401-411, Year 2013
Publish dateJun 5, 2012 (structure data deposition date)
AuthorsZheng, W. / Feng, X. / Qiu, L. / Pan, Z. / Wang, R. / Lin, S. / Hou, D. / Jin, L. / Li, Y.
External linksDiabetologia / PubMed:23178929
MethodsX-ray diffraction
Resolution2.84 Å
Structure data

PDB-4fgy:
Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity
Method: X-RAY DIFFRACTION / Resolution: 2.84 Å

Chemicals

ChemComp-0W3:
(4R,6S,8S,12R,14R,16Z,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid / antibiotic*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTranscription/Transferase/Antibiotic / PPAR LBD / nuclear receptor fold / ligand binding / gene transcription / Transcription-Transferase-Antibiotic complex

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