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Structure paper

TitlePreconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 264-269, Year 2013
Publish dateOct 14, 2012 (structure data deposition date)
AuthorsSchmidt, A.G. / Xu, H. / Khan, A.R. / O'Donnell, T. / Khurana, S. / King, L.R. / Manischewitz, J. / Golding, H. / Suphaphiphat, P. / Carfi, A. ...Schmidt, A.G. / Xu, H. / Khan, A.R. / O'Donnell, T. / Khurana, S. / King, L.R. / Manischewitz, J. / Golding, H. / Suphaphiphat, P. / Carfi, A. / Settembre, E.C. / Dormitzer, P.R. / Kepler, T.B. / Zhang, R. / Moody, M.A. / Haynes, B.F. / Liao, H.X. / Shaw, D.E. / Harrison, S.C.
External linksProc. Natl. Acad. Sci. USA / PubMed:23175789
MethodsX-ray diffraction
Resolution2.497 - 3.6 Å
Structure data

PDB-4hk0:
UCA Fab (unbound) from CH65-CH67 Lineage
Method: X-RAY DIFFRACTION / Resolution: 2.497 Å

PDB-4hk3:
I2 Fab (unbound) from CH65-CH67 Lineage
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-4hkb:
CH67 Fab (unbound) from the CH65-67 Lineage
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

PDB-4hkx:
Influenza hemagglutinin in complex with CH67 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • influenza a virus
KeywordsIMMUNE SYSTEM / Fab fragment / VIRAL PROTEIN/IMMUNE SYSTEM / VIRAL PROTEIN-IMMUNE SYSTEM complex

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