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-Structure paper
| Title | Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 7523-7529, Year 2012 |
| Publish date | Sep 10, 2012 (structure data deposition date) |
 Authors | Bhattacharya, S.K. / Aspnes, G.E. / Bagley, S.W. / Boehm, M. / Brosius, A.D. / Buckbinder, L. / Chang, J.S. / Dibrino, J. / Eng, H. / Frederick, K.S. ...Bhattacharya, S.K. / Aspnes, G.E. / Bagley, S.W. / Boehm, M. / Brosius, A.D. / Buckbinder, L. / Chang, J.S. / Dibrino, J. / Eng, H. / Frederick, K.S. / Griffith, D.A. / Griffor, M.C. / Guimaraes, C.R. / Guzman-Perez, A. / Han, S. / Kalgutkar, A.S. / Klug-McLeod, J. / Garcia-Irizarry, C. / Li, J. / Lippa, B. / Price, D.A. / Southers, J.A. / Walker, D.P. / Wei, L. / Xiao, J. / Zawistoski, M.P. / Zhao, X. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:23153798 |
| Methods | X-ray diffraction |
| Resolution | 1.99 - 2 Å |
| Structure data |  PDB-4h1j:  PDB-4h1m: |
| Chemicals |  ChemComp-0YH:  ChemComp-HOH:  ChemComp-0YJ: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)