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Structure paper

TitlePrecursor of Ether Phospholipids is Synthesized by a Flavoenzyme Through Covalent Catalysis.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 18791-, Year 2012
Publish dateSep 28, 2012 (structure data deposition date)
AuthorsNenci, S. / Piano, V. / Rosati, S. / Aliverti, A. / Pandini, V. / Fraaije, M.W. / Heck, A.J.R. / Edmondson, D.E. / Mattevi, A.
External linksProc. Natl. Acad. Sci. USA / PubMed:23112191
MethodsX-ray diffraction
Resolution1.9 - 2.41 Å
Structure data

PDB-4bby:
MAMMALIAN ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE: WILD-TYPE
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-4bc7:
MAMMALIAN ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE: Arg419His mutant
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4bc9:
MAMMALIAN ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE: WILD-TYPE, ADDUCT WITH CYANOETHYL
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

PDB-4bca:
MAMMALIAN ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE: Tyr578Phe mutant
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-1DO:
1-DODECANOL

ChemComp-CNV:
propanenitrile

ChemComp-CL:
Unknown entry

Source
  • cavia porcellus (domestic guinea pig)
KeywordsTRANSFERASE / PLASMALOGEN / FLAVIN / PEROXISOME

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