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Structure paper

TitleNeuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 19, Page 1293-1299, Year 2012
Publish dateSep 6, 2012 (structure data deposition date)
AuthorsJanssen, B.J.C. / Malinauskas, T. / Weir, G.A. / Cader, M.Z. / Siebold, C. / Jones, E.Y.
External linksNat. Struct. Mol. Biol. / PubMed:23104057
MethodsX-ray diffraction
Resolution2.7 - 7 Å
Structure data

PDB-4gz8:
Mouse Semaphorin 3A, domains Sema-PSI-IG
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-4gz9:
Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-4gza:
Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1
Method: X-RAY DIFFRACTION / Resolution: 7 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsSIGNALING PROTEIN / sema / multi-domain / cell-cell signaling / plexin / glycosilated / extracellular / Semaphorin / VEGF / transmembrane / ternary complex / mammalian / glycosilation

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