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TitleRedirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.
Journal, issue, pagesNat. Chem. Biol., Vol. 8, Page 990-998, Year 2012
Publish dateJan 12, 2011 (structure data deposition date)
AuthorsJunttila, I.S. / Creusot, R.J. / Moraga, I. / Bates, D.L. / Wong, M.T. / Alonso, M.N. / Suhoski, M.M. / Lupardus, P. / Meier-Schellersheim, M. / Engleman, E.G. ...Junttila, I.S. / Creusot, R.J. / Moraga, I. / Bates, D.L. / Wong, M.T. / Alonso, M.N. / Suhoski, M.M. / Lupardus, P. / Meier-Schellersheim, M. / Engleman, E.G. / Utz, P.J. / Fathman, C.G. / Paul, W.E. / Garcia, K.C.
External linksNat. Chem. Biol. / PubMed:23103943
MethodsX-ray diffraction
Resolution3.245 Å
Structure data

PDB-3qb7:
Interleukin-4 mutant RGA bound to cytokine receptor common gamma
Method: X-RAY DIFFRACTION / Resolution: 3.245 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsCYTOKINE/CYTOKINE RECEPTOR / cytokine signaling / IL-4Ralpha / CYTOKINE-CYTOKINE RECEPTOR complex

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