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TitleLocal and Global Interpretations of a Disease-Causing Mutation near the Ligand Entry Path in Hyperpolarization-Activated cAMP-Gated Channel.
Journal, issue, pagesStructure, Vol. 20, Page 2116-2123, Year 2012
Publish dateSep 28, 2012 (structure data deposition date)
AuthorsXu, X. / Marni, F. / Wu, S. / Su, Z. / Musayev, F. / Shrestha, S. / Xie, C. / Gao, W. / Liu, Q. / Zhou, L.
External linksStructure / PubMed:23103389
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-4hbn:
Crystal structure of the human HCN4 channel C-terminus carrying the S672R mutation
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-CMP:
ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsNEUROPEPTIDE / cAMP binding / cAMP

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