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-Structure paper
Title | Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 9831-9837, Year 2012 |
Publish date | Mar 20, 2012 (structure data deposition date) |
![]() | Fish, P.V. / Filippakopoulos, P. / Bish, G. / Brennan, P.E. / Bunnage, M.E. / Cook, A.S. / Federov, O. / Gerstenberger, B.S. / Jones, H. / Knapp, S. ...Fish, P.V. / Filippakopoulos, P. / Bish, G. / Brennan, P.E. / Bunnage, M.E. / Cook, A.S. / Federov, O. / Gerstenberger, B.S. / Jones, H. / Knapp, S. / Marsden, B. / Nocka, K. / Owen, D.R. / Philpott, M. / Picaud, S. / Primiano, M.J. / Ralph, M.J. / Sciammetta, N. / Trzupek, J.D. |
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Methods | X-ray diffraction |
Resolution | 1.59 - 1.92 Å |
Structure data | ![]() PDB-4e96: ![]() PDB-4hbv: ![]() PDB-4hbw: ![]() PDB-4hbx: ![]() PDB-4hby: |
Chemicals | ![]() ChemComp-0NS: ![]() ChemComp-NA: ![]() ChemComp-DMS: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-15E: ![]() ChemComp-14Z: ![]() ChemComp-K: ![]() ChemComp-14X: ![]() ChemComp-13F: |
Source |
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![]() | PROTEIN BINDING/INHIBITOR / BROMODOMAIN / CAP / HUNK1 / MCAP / MITOTIC CHROMOSOME ASSOCIATED PROTEIN / JQ1 / BETSOFF1 / STRUCTURAL GENOMICS CONSORTIUM / SGC / CELL CYCLE / PROTEIN BINDING-INHIBITOR complex / SIGNALING PROTEIN/INHIBITOR / SIGNALING PROTEIN-INHIBITOR complex |