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TitleDe Novo GTP Biosynthesis is Critical for Virulence of the Fungal Pathogen Cryptococcus Neoformans
Journal, issue, pagesPlos Pathog., Vol. 8, Page 2957-, Year 2012
Publish dateJan 15, 2012 (structure data deposition date)
AuthorsMorrow, C.A. / Valkov, E. / Stamp, A. / Chow, E.W.L. / Lee, I.R. / Wronski, A. / Williams, S.J. / Hill, J.M. / Djordjevic, J.T. / Kappler, U. ...Morrow, C.A. / Valkov, E. / Stamp, A. / Chow, E.W.L. / Lee, I.R. / Wronski, A. / Williams, S.J. / Hill, J.M. / Djordjevic, J.T. / Kappler, U. / Kobe, B. / Fraser, J.A.
External linksPlos Pathog. / PubMed:23071437
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-4af0:
Crystal structure of cryptococcal inosine monophosphate dehydrogenase
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-MOA:
MYCOPHENOLIC ACID / medication, immunosuppressant*YM

ChemComp-IMP:
INOSINIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • cryptococcus neoformans (fungus)
KeywordsOXIDOREDUCTASE / GTP BIOSYNTHESIS / DRUG RESISTANCE

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