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-Structure paper
Title | Serine is a natural ligand and allosteric activator of pyruvate kinase M2. |
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Journal, issue, pages | Nature, Vol. 491, Page 458-462, Year 2012 |
Publish date | Jul 13, 2012 (structure data deposition date) |
Authors | Chaneton, B. / Hillmann, P. / Zheng, L. / Martin, A.C.L. / Maddocks, O.D.K. / Chokkathukalam, A. / Coyle, J.E. / Jankevics, A. / Holding, F.P. / Vousden, K.H. ...Chaneton, B. / Hillmann, P. / Zheng, L. / Martin, A.C.L. / Maddocks, O.D.K. / Chokkathukalam, A. / Coyle, J.E. / Jankevics, A. / Holding, F.P. / Vousden, K.H. / Frezza, C. / O'Reilly, M. / Gottlieb, E. |
External links | Nature / PubMed:23064226 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-4b2d: |
Chemicals | ChemComp-SER: ChemComp-FBP: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / TUMOUR / PKM2 / GLYCOLYSIS |