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TitleDiscovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 10090-10107, Year 2012
Publish dateOct 8, 2012 (structure data deposition date)
AuthorsHanan, E.J. / van Abbema, A. / Barrett, K. / Blair, W.S. / Blaney, J. / Chang, C. / Eigenbrot, C. / Flynn, S. / Gibbons, P. / Hurley, C.A. ...Hanan, E.J. / van Abbema, A. / Barrett, K. / Blair, W.S. / Blaney, J. / Chang, C. / Eigenbrot, C. / Flynn, S. / Gibbons, P. / Hurley, C.A. / Kenny, J.R. / Kulagowski, J. / Lee, L. / Magnuson, S.R. / Morris, C. / Murray, J. / Pastor, R.M. / Rawson, T. / Siu, M. / Ultsch, M. / Zhou, A. / Sampath, D. / Lyssikatos, J.P.
External linksJ. Med. Chem. / PubMed:23061660
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4hge:
JAK2 kinase (JH1 domain) in complex with compound 8
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-15V:
N-[1-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / protein kinase / phosphotransfer / TRANSFERASE-TRANSFERASE INHIBITOR complex

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