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Structure paper

TitleStructural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope.
Journal, issue, pagesPlos Pathog., Vol. 8, Page e1002930-e1002930, Year 2012
Publish dateJun 1, 2012 (structure data deposition date)
AuthorsAustin, S.K. / Dowd, K.A. / Shrestha, B. / Nelson, C.A. / Edeling, M.A. / Johnson, S. / Pierson, T.C. / Diamond, M.S. / Fremont, D.H.
External linksPlos Pathog. / PubMed:23055922
MethodsX-ray diffraction
Resolution2.5 - 3.8 Å
Structure data

PDB-4ffy:
Crystal structure of DENV1-E111 single chain variable fragment bound to DENV-1 DIII, strain 16007.
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-4ffz:
Crystal Structure of DENV1-E111 fab fragment bound to DENV-1 DIII (Western Pacific-74 strain).
Method: X-RAY DIFFRACTION / Resolution: 3.8 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • dengue virus 1
KeywordsIMMUNE SYSTEM/VIRAL PROTEIN / Viral envelope proteins / structural genomics / antibody epitopes / Flavivirus / Dengue virus / NIAID / National Institute of Allergy and Infectious Diseases / Center for Structural Genomics of Infectious Diseases / CSGID / IMMUNE SYSTEM / IMMUNE SYSTEM-VIRAL PROTEIN complex / antibody fab fragment / immunoglobulin-like domain / viral envelope protein / virion

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