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TitleOptimization of Imidazo[4,5-B]Pyridine-Based Kinase Inhibitors: Identification of a Dual Flt3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia.
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 8721-, Year 2012
Publish dateJul 2, 2012 (structure data deposition date)
AuthorsBavetsias, V. / Crumpler, S. / Sun, C. / Avery, S. / Atrash, B. / Faisal, A. / Moore, A.S. / Kosmopoulou, M. / Brown, N. / Sheldrake, P.W. ...Bavetsias, V. / Crumpler, S. / Sun, C. / Avery, S. / Atrash, B. / Faisal, A. / Moore, A.S. / Kosmopoulou, M. / Brown, N. / Sheldrake, P.W. / Bush, K. / Henley, A. / Box, G. / Valenti, M. / De Haven Brandon, A. / Raynaud, F.I. / Workman, P. / Eccles, S.A. / Bayliss, R. / Linardopoulos, S. / Blagg, J.
External linksJ. Med. Chem. / PubMed:23043539
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-4b0g:
Complex of Aurora-A bound to an Imidazopyridine-based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-VEK:
6-bromo-2-(1-methyl-1H-imidazol-5-yl)-7-{4-[(5-methyl-1,2-oxazol-3-yl)methyl]piperazin-1-yl}-1H-imidazo[4,5-b]pyridine

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / MITOSIS

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