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TitleMarburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism.
Journal, issue, pagesPlos Pathog., Vol. 8, Page e1002916-e1002916, Year 2012
Publish dateAug 7, 2012 (structure data deposition date)
AuthorsBale, S. / Julien, J.P. / Bornholdt, Z.A. / Kimberlin, C.R. / Halfmann, P. / Zandonatti, M.A. / Kunert, J. / Kroon, G.J. / Kawaoka, Y. / Macrae, I.J. ...Bale, S. / Julien, J.P. / Bornholdt, Z.A. / Kimberlin, C.R. / Halfmann, P. / Zandonatti, M.A. / Kunert, J. / Kroon, G.J. / Kawaoka, Y. / Macrae, I.J. / Wilson, I.A. / Saphire, E.O.
External linksPlos Pathog. / PubMed:23028316
MethodsX-ray diffraction
Resolution1.65 - 2.5 Å
Structure data

PDB-4gh9:
Crystal structure of Marburg virus VP35 RNA binding domain
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-4gha:
Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • marburg virus
  • marburg virus - musoke
  • kenya, 1980
KeywordsVIRAL PROTEIN / RNA BINDING PROTEIN / Viral polymerase / Interferon inhibition / double stranded viral RNA / RNA BINDING PROTEIN/RNA / dsRNA / RNA BINDING PROTEIN-RNA complex

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