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Structure paper

TitleRezymogenation of active urokinase induced by an inhibitory antibody
Journal, issue, pagesBiochem. J., Vol. 449, Page 161-166, Year 2013
Publish dateFeb 23, 2012 (structure data deposition date)
AuthorsJiang, L. / Botkjaer, K.A. / Andersen, L.M. / Yuan, C. / Andreasen, P.A. / Huang, M.
External linksBiochem. J. / PubMed:23016918
MethodsX-ray diffraction
Resolution1.93 - 2.97 Å
Structure data

PDB-4dva:
The crystal structure of human urokinase-type plasminogen activator catalytic domain
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

PDB-4dvb:
The crystal structure of the Fab fragment of pro-uPA antibody mAb-112
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

PDB-4dw2:
The crystal structure of uPA in complex with the Fab fragment of mAb-112
Method: X-RAY DIFFRACTION / Resolution: 2.97 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsHYDROLASE / Plasminogen activation / Protease / Serine protease / IMMUNE SYSTEM / HYDROLASE/IMMUNE SYSTEM / urokinase-type plasminogen activator / antibody / zymogen / HYDROLASE-IMMUNE SYSTEM complex

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