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-Structure paper
Title | Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 6721-6727, Year 2012 |
Publish date | Apr 27, 2012 (structure data deposition date) |
![]() | Sund, C. / Belda, O. / Borkakoti, N. / Lindberg, J. / Derbyshire, D. / Vrang, L. / Hamelink, E. / Hgren, C. / Woestenenk, E. / Wikstrom, K. ...Sund, C. / Belda, O. / Borkakoti, N. / Lindberg, J. / Derbyshire, D. / Vrang, L. / Hamelink, E. / Hgren, C. / Woestenenk, E. / Wikstrom, K. / Eneroth, A. / Lindstrom, E. / Kalayanov, G. |
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Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | ![]() PDB-4ewo: ![]() PDB-4exg: |
Chemicals | ![]() ChemComp-996: ![]() ChemComp-HOH: ![]() ChemComp-916: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / BACE / BETA-SECRETASE / STATINE / INHIBITOR / ASPARTYL PROTEASE / GLYCOPROTEIN / MEMBRANE / PROTEASE / TRANSMEMBRANE / ZYMOGEN / HYDROLASE-HYDROLASE INHIBITOR complex |