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-Structure paper
Title | Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 22, Page 6705-6711, Year 2012 |
Publish date | Aug 15, 2012 (structure data deposition date) |
Authors | Surivet, J.P. / Lange, R. / Hubschwerlen, C. / Keck, W. / Specklin, J.L. / Ritz, D. / Bur, D. / Locher, H. / Seiler, P. / Strasser, D.S. ...Surivet, J.P. / Lange, R. / Hubschwerlen, C. / Keck, W. / Specklin, J.L. / Ritz, D. / Bur, D. / Locher, H. / Seiler, P. / Strasser, D.S. / Prade, L. / Kohl, C. / Schmitt, C. / Chapoux, G. / Ilhan, E. / Ekambaram, N. / Athanasiou, A. / Knezevic, A. / Sabato, D. / Chambovey, A. / Gaertner, M. / Enderlin, M. / Boehme, M. / Sippel, V. / Wyss, P. |
External links | Bioorg. Med. Chem. Lett. / PubMed:23006603 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2 Å |
Structure data | PDB-4glw: PDB-4glx: |
Chemicals | ChemComp-SO4: ChemComp-0XT: ChemComp-NMN: ChemComp-HOH: ChemComp-ZN: ChemComp-0XS: |
Source |
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Keywords | LIGASE/LIGASE INHIBITOR / DNA ligase A / inhibitor / LIGASE-LIGASE INHIBITOR complex / LIGASE/LIGASE INHIBITOR/DNA / LIGASE-LIGASE INHIBITOR-DNA complex |