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-Structure paper
Title | Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy. |
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Journal, issue, pages | Chem. Biol., Vol. 19, Page 1187-1198, Year 2012 |
Publish date | Jul 10, 2012 (structure data deposition date) |
Authors | Kung, C. / Hixon, J. / Choe, S. / Marks, K. / Gross, S. / Murphy, E. / Delabarre, B. / Cianchetta, G. / Sethumadhavan, S. / Wang, X. ...Kung, C. / Hixon, J. / Choe, S. / Marks, K. / Gross, S. / Murphy, E. / Delabarre, B. / Cianchetta, G. / Sethumadhavan, S. / Wang, X. / Yan, S. / Gao, Y. / Fang, C. / Wei, W. / Jiang, F. / Wang, S. / Qian, K. / Saunders, J. / Driggers, E. / Woo, H.K. / Kunii, K. / Murray, S. / Yang, H. / Yen, K. / Liu, W. / Cantley, L.C. / Vander Heiden, M.G. / Su, S.M. / Jin, S. / Salituro, F.G. / Dang, L. |
External links | Chem. Biol. / PubMed:22999886 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-4g1n: |
Chemicals | ChemComp-OXL: ChemComp-MG: ChemComp-NZT: ChemComp-HOH: |
Source |
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Keywords | Transferase/Activator / pyruvate kinase / aerobic glycolysis / activator / cancer metabolism / phosphorylation of pyruvate / Transferase-Activator complex |