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TitleInsights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha-Helix Structure in Its Cleavage Site with Inefficient HA1/HA2 Cleavage.
Journal, issue, pagesJ. Virol., Vol. 86, Page 12861-12870, Year 2012
Publish dateMay 7, 2012 (structure data deposition date)
AuthorsLu, X. / Shi, Y. / Gao, F. / Xiao, H. / Wang, M. / Qi, J. / Gao, G.F.
External linksJ. Virol. / PubMed:22993148
MethodsX-ray diffraction
Resolution1.7 - 1.999 Å
Structure data

PDB-4f23:
Influenza A virus hemagglutinin H16 HA0 structure with an alpha-helix conformation in the cleavage site: a potential drug target
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4fiu:
The structure of hemagglutinin of H16 subtype influenza virus with V327G mutation
Method: X-RAY DIFFRACTION / Resolution: 1.999 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • influenza a virus
KeywordsVIRAL PROTEIN / hemagglutinin / sialic acid / glycolysation / membrane / membrane glycoprotein / receptor binding / virus fusion

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