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TitlePreparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3K beta inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 22, Page 6381-6384, Year 2012
Publish dateJul 10, 2012 (structure data deposition date)
AuthorsCertal, V. / Halley, F. / Virone-Oddos, A. / Thompson, F. / Filoche-Romme, B. / El-Ahmad, Y. / Carry, J.C. / Delorme, C. / Karlsson, A. / Abecassis, P.Y. ...Certal, V. / Halley, F. / Virone-Oddos, A. / Thompson, F. / Filoche-Romme, B. / El-Ahmad, Y. / Carry, J.C. / Delorme, C. / Karlsson, A. / Abecassis, P.Y. / Vincent, L. / Bonnevaux, H. / Nicolas, J.P. / Morales, R. / Michot, N. / Vade, I. / Louboutin, A. / Perron, S. / Doerflinger, G. / Tric, B. / Monget, S. / Lengauer, C. / Schio, L.
External linksBioorg. Med. Chem. Lett. / PubMed:22981333
MethodsX-ray diffraction
Resolution3.4 Å
Structure data

PDB-4g11:
X-ray structure of PI3K-gamma bound to a 4-(morpholin-4-yl)- (6-oxo-1,6-dihydropyrimidin-2-yl)amide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-0W7:
2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / PHOSPHOINOSITIDE 3-KINASE GAMMA / SECONDARY MESSENGER GENERATION / Transferase-Transferase Inhibitor complex

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