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-Structure paper
Title | The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase. |
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Journal, issue, pages | J. Biol. Chem., Vol. 287, Page 37447-37457, Year 2012 |
Publish date | Jun 20, 2012 (structure data deposition date) |
Authors | Epstein, L.F. / Chen, H. / Emkey, R. / Whittington, D.A. |
External links | J. Biol. Chem. / PubMed:22932897 |
Methods | X-ray diffraction |
Resolution | 1.7 - 2.6 Å |
Structure data | PDB-4fnw: PDB-4fnx: PDB-4fny: PDB-4fnz: |
Chemicals | ChemComp-GOL: ChemComp-HOH: ChemComp-I3K: ChemComp-NZF: |
Source |
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Keywords | TRANSFERASE / receptor tyrosine kinase / inhibitor / crizotinib / neuroblastoma / CD246 / phosphotransferase / NPM-ALK / EML4-ALK / Transferase/Inhibitor / Transferase-Inhibitor complex |