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Structure paper

TitleThe R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 37447-37457, Year 2012
Publish dateJun 20, 2012 (structure data deposition date)
AuthorsEpstein, L.F. / Chen, H. / Emkey, R. / Whittington, D.A.
External linksJ. Biol. Chem. / PubMed:22932897
MethodsX-ray diffraction
Resolution1.7 - 2.6 Å
Structure data

PDB-4fnw:
Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-4fnx:
Crystal structure of the apo R1275Q anaplastic lymphoma kinase catalytic domain
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4fny:
Crystal structure of the R1275Q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-4fnz:
Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-I3K:
N-(4-chlorophenyl)-5-[(6,7-dimethoxyquinolin-4-yl)oxy]-1,3-benzoxazol-2-amine

ChemComp-NZF:
(3S)-N-[3-(trifluoromethoxy)benzyl]-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / receptor tyrosine kinase / inhibitor / crizotinib / neuroblastoma / CD246 / phosphotransferase / NPM-ALK / EML4-ALK / Transferase/Inhibitor / Transferase-Inhibitor complex

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