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TitleChemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page 14779-14784, Year 2012
Publish dateAug 14, 2012 (structure data deposition date)
AuthorsMandal, K. / Uppalapati, M. / Ault-Riche, D. / Kenney, J. / Lowitz, J. / Sidhu, S.S. / Kent, S.B.
External linksProc. Natl. Acad. Sci. USA / PubMed:22927390
MethodsX-ray diffraction
Resolution1.6 - 1.9 Å
Structure data

PDB-4gln:
Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21/n
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-4gls:
Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-4glu:
Crystal structure of the mirror image form of VEGF-A
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-TFA:
trifluoroacetic acid

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsGrowth Factor/Inhibitor / heterochiral protein-protein complex / D-protein antagonist / Growth Factor-Inhibitor complex / DE NOVO PROTEIN / D-protein / covalent dimer / cysteine knot protein / growth factor

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