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Title | Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (C-met) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-Ylmethyl)-1H-[1,2, 3]Triazolo[4,5-B]Pyrazin-6-Yl)-1H-Pyrazol-1-Yl)Ethanol (Pf-04217903) for the Treatment of Cancer. |
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Journal, issue, pages | J. Med. Chem., Vol. 55, Page 8091-, Year 2012 |
Publish date | Aug 16, 2011 (structure data deposition date) |
Authors | Cui, J.J. / Mctigue, M. / Nambu, M. / Tran-Dube, M. / Pairish, M. / Shen, H. / Jia, L. / Cheng, H. / Hoffman, J. / Le, P. ...Cui, J.J. / Mctigue, M. / Nambu, M. / Tran-Dube, M. / Pairish, M. / Shen, H. / Jia, L. / Cheng, H. / Hoffman, J. / Le, P. / Jalaie, M. / Goetz, G.H. / Ryan, K. / Grodsky, N. / Deng, Y. / Parker, M. / Timofeevski, S. / Murray, B.W. / Yamazaki, S. / Aguirre, S. / Li, Q. / Zou, H. / Christensen, J. |
External links | J. Med. Chem. / PubMed:22924734 |
Methods | X-ray diffraction |
Resolution | 1.8 - 1.9 Å |
Structure data | PDB-3zxz: PDB-3zze: PDB-4aoi: PDB-4ap7: |
Chemicals | ChemComp-KRW: ChemComp-HOH: ChemComp-6XP: ChemComp-4K0: ChemComp-F47: |
Source |
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Keywords | TRANSFERASE / INHIBITOR / KINASE INHIBITOR |