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TitleRational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 134, Page 14734-14737, Year 2012
Publish dateJul 13, 2012 (structure data deposition date)
AuthorsMuppidi, A. / Doi, K. / Edwardraja, S. / Drake, E.J. / Gulick, A.M. / Wang, H.G. / Lin, Q.
External linksJ. Am. Chem. Soc. / PubMed:22920569
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4g35:
Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-4BP:
4,4'-bis(bromomethyl)biphenyl

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsApoptosis/Inhibitor / APOPTOSIS / BH3 domain / Bcl-2 family / Apoptosis-Inhibitor complex

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