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Structure paper

TitleAllosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 19, Page 938-947, Year 2012
Publish dateOct 31, 2011 (structure data deposition date)
AuthorsElegheert, J. / Bracke, N. / Pouliot, P. / Gutsche, I. / Shkumatov, A.V. / Tarbouriech, N. / Verstraete, K. / Bekaert, A. / Burmeister, W.P. / Svergun, D.I. ...Elegheert, J. / Bracke, N. / Pouliot, P. / Gutsche, I. / Shkumatov, A.V. / Tarbouriech, N. / Verstraete, K. / Bekaert, A. / Burmeister, W.P. / Svergun, D.I. / Lambrecht, B.N. / Vergauwen, B. / Savvides, S.N.
External linksNat. Struct. Mol. Biol. / PubMed:22902366
MethodsX-ray diffraction
Resolution2.75 - 4.5 Å
Structure data

PDB-3uez:
Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine in complex with the viral receptor BARF1
Method: X-RAY DIFFRACTION / Resolution: 3.414 Å

PDB-3uf2:
Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-3uf5:
Crystal structure of the mouse Colony-Stimulating Factor 1 (mCSF-1) cytokine
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-4adf:
CRYSTAL STRUCTURE OF THE HUMAN COLONY-STIMULATING FACTOR 1 (hCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1
Method: X-RAY DIFFRACTION / Resolution: 4.4 Å

PDB-4adq:
CRYSTAL STRUCTURE OF THE MOUSE COLONY-STIMULATING FACTOR 1 (MCSF-1) CYTOKINE IN COMPLEX WITH THE VIRAL RECEPTOR BARF1
Method: X-RAY DIFFRACTION / Resolution: 4.5 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

Source
  • human herpesvirus 4 (Epstein-Barr virus)
  • homo sapiens (human)
  • mus musculus (house mouse)
  • human gammaherpesvirus 4 (Epstein-Barr virus)
KeywordsCYTOKINE RECEPTOR/CYTOKINE / VIRAL RECEPTOR / RTKIII / EXTRACELLULAR / CYTOKINE RECEPTOR-CYTOKINE complex / CYTOKINE / FOUR-HELIX BUNDLE / GLYCOPROTEIN / IMMUNOGLOBULIN DOMAIN / ONCOGENE / RECEPTOR / CYTOKINE/SIGNALING / PROTEIN COMPLEX / hematopoietic cytokine / IMMUNE SYSTEM/RECEPTOR / IMMUNE SYSTEM-RECEPTOR COMPLEX

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