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Structure paper

TitleCrystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs.
Journal, issue, pagesBiochemistry, Vol. 51, Page 7383-7392, Year 2012
Publish dateMay 21, 2012 (structure data deposition date)
AuthorsKoch, B. / Kolenko, P. / Buchholz, M. / Ruiz Carrillo, D. / Parthier, C. / Wermann, M. / Rahfeld, J.U. / Reuter, G. / Schilling, S. / Stubbs, M.T. / Demuth, H.U.
External linksBiochemistry / PubMed:22897232
MethodsX-ray diffraction
Resolution1.65 - 2.1 Å
Structure data

PDB-4f9u:
Structure of glycosylated glutaminyl cyclase from Drosophila melanogaster
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4f9v:
Structure of C113A/C136A mutant variant of glycosylated glutaminyl cyclase from Drosophila melanogaster
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4fai:
Crystal structure of mitochondrial isoform of glutaminyl cyclase from Drosophila melanogaster
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-4fbe:
Crystal structure of the C136A/C164A variant of mitochondrial isoform of glutaminyl cyclase from Drosophila melanogaster
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PBD:
1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-CL:
Unknown entry

Source
  • drosophila melanogaster (fruit fly)
KeywordsTRANSFERASE / HYDROLASE / alpha/beta hydrolase / pGlu formation / PE / Alzheimer's Disease / pyroglutamate / pGlu-amyloid / glycosylation

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