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TitleHighly potent aminopyridines as Syk kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 22, Page 5419-5423, Year 2012
Publish dateMay 11, 2012 (structure data deposition date)
AuthorsCastillo, M. / Forns, P. / Erra, M. / Mir, M. / Lopez, M. / Maldonado, M. / Orellana, A. / Carreno, C. / Ramis, I. / Miralpeix, M. / Vidal, B.
External linksBioorg. Med. Chem. Lett. / PubMed:22877633
MethodsX-ray diffraction
Resolution2.37 Å
Structure data

PDB-4f4p:
SYK in COMPLEX WITH LIGAND LASW836
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

Chemicals

ChemComp-0SB:
N-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Tyrosine-protein kinase / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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