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TitlePotent and highly selective benzimidazole inhibitors of PI3-kinase delta.
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 7686-7695, Year 2012
Publish dateJul 26, 2012 (structure data deposition date)
AuthorsMurray, J.M. / Sweeney, Z.K. / Chan, B.K. / Balazs, M. / Bradley, E. / Castanedo, G. / Chabot, C. / Chantry, D. / Flagella, M. / Goldstein, D.M. ...Murray, J.M. / Sweeney, Z.K. / Chan, B.K. / Balazs, M. / Bradley, E. / Castanedo, G. / Chabot, C. / Chantry, D. / Flagella, M. / Goldstein, D.M. / Kondru, R. / Lesnick, J. / Li, J. / Lucas, M.C. / Nonomiya, J. / Pang, J. / Price, S. / Salphati, L. / Safina, B. / Savy, P.P. / Seward, E.M. / Ultsch, M. / Sutherlin, D.P.
External linksJ. Med. Chem. / PubMed:22877085
MethodsX-ray diffraction
Resolution2.438 Å
Structure data

PDB-4gb9:
Potent and Highly Selective Benzimidazole Inhibitors of PI3K-delta
Method: X-RAY DIFFRACTION / Resolution: 2.438 Å

Chemicals

ChemComp-0WR:
2-[1-({2-[2-(dimethylamino)-1H-benzimidazol-1-yl]-9-methyl-6-(morpholin-4-yl)-9H-purin-8-yl}methyl)piperidin-4-yl]propan-2-ol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordstransferase/transferase inhibitor / kinase p110 gamma-isoform / kinase / lipid kinase / transferase-transferase inhibitor complex

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