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-Structure paper
Title | Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells. |
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Journal, issue, pages | Biochemistry, Vol. 51, Page 6880-6888, Year 2012 |
Publish date | Aug 10, 2012 (structure data deposition date) |
Authors | Archer, C.R. / Groll, M. / Stein, M.L. / Schellenberg, B. / Clerc, J. / Kaiser, M. / Kondratyuk, T.P. / Pezzuto, J.M. / Dudler, R. / Bachmann, A.S. |
External links | Biochemistry / PubMed:22870914 |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-4gk7: |
Chemicals | ChemComp-HOH: |
Source |
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Keywords | hydrolase/hydrolase inhibitor / proteasome / cancer / protein degradation / inhibition / natural product derivative / NTN-hydrolase / hydrolase-hydrolase inhibitor complex / 12-membered dipeptide-macrolactam |