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TitleActivity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells.
Journal, issue, pagesBiochemistry, Vol. 51, Page 6880-6888, Year 2012
Publish dateAug 10, 2012 (structure data deposition date)
AuthorsArcher, C.R. / Groll, M. / Stein, M.L. / Schellenberg, B. / Clerc, J. / Kaiser, M. / Kondratyuk, T.P. / Pezzuto, J.M. / Dudler, R. / Bachmann, A.S.
External linksBiochemistry / PubMed:22870914
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-4gk7:
yeast 20S proteasome in complex with the Syringolin-Glidobactin chimera
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
  • synthetic construct (others)
Keywordshydrolase/hydrolase inhibitor / proteasome / cancer / protein degradation / inhibition / natural product derivative / NTN-hydrolase / hydrolase-hydrolase inhibitor complex / 12-membered dipeptide-macrolactam

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