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TitleP6981, an arylstibonic acid, is a novel low nanomolar inhibitor of cAMP response element-binding protein binding to DNA.
Journal, issue, pagesMol. Pharmacol., Vol. 82, Page 814-823, Year 2012
Publish dateJul 25, 2014 (structure data deposition date)
AuthorsZhao, J. / Stagno, J.R. / Varticovski, L. / Nimako, E. / Rishi, V. / McKinnon, K. / Akee, R. / Shoemaker, R.H. / Ji, X. / Vinson, C.
External linksMol. Pharmacol. / PubMed:22851716
MethodsX-ray diffraction
Resolution3.301 Å
Structure data

PDB-4u5t:
Crystal Structure of VBP Leucine Zipper with Bound Arylstibonic Acid
Method: X-RAY DIFFRACTION / Resolution: 3.301 Å

Chemicals

ChemComp-3CG:
(2Z)-3-{3-[dihydroxy(oxido)-lambda~5~-stibanyl]phenyl}prop-2-enoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/TRANSCRIPTION Inhibitor / leucine zipper / B-ZIP transcription factor / vitellogenin gene-binding protein (VBP) / inhibitor / TRANSCRIPTION-TRANSCRIPTION Inhibitor complex

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