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Structure paper

TitleStructural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 109, Page E2248-, Year 2012
Publish dateJul 16, 2011 (structure data deposition date)
AuthorsKummer, L. / Parizek, P. / Rube, P. / Millgramm, B. / Prinz, A. / Mittl, P.R. / Kaufholz, M. / Zimmermann, B. / Herberg, F.W. / Pluckthun, A.
External linksProc. Natl. Acad. Sci. USA / PubMed:22843676
MethodsX-ray diffraction
Resolution1.97 - 2.72 Å
Structure data

PDB-3zu7:
Crystal structure of a designed selected Ankyrin Repeat protein in complex with the MAP kinase ERK2
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-3zuv:
Crystal structure of a designed selected Ankyrin Repeat protein in complex with the phosphorylated MAP kinase ERK2
Method: X-RAY DIFFRACTION / Resolution: 2.72 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • rattus norvegicus (Norway rat)
  • synthetic construct (others)
KeywordsTRANSFERASE/DE NOVO PROTEIN / TRANSFERASE-DE NOVO PROTEIN COMPLEX / TRANSFERASE / SELECTED BINDER / PROTEIN DESIGN / DE NOVO PROTEIN/TRANSFERASE / DE NOVO PROTEIN-TRANSFERASE COMPLEX / ANKYRIN REPEAT PROTEIN

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