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TitleExome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Journal, issue, pagesNat. Genet., Vol. 44, Page 1006-1014, Year 2012
Publish dateJun 3, 2011 (structure data deposition date)
AuthorsKrauthammer, M. / Kong, Y. / Ha, B.H. / Evans, P. / Bacchiocchi, A. / McCusker, J.P. / Cheng, E. / Davis, M.J. / Goh, G. / Choi, M. ...Krauthammer, M. / Kong, Y. / Ha, B.H. / Evans, P. / Bacchiocchi, A. / McCusker, J.P. / Cheng, E. / Davis, M.J. / Goh, G. / Choi, M. / Ariyan, S. / Narayan, D. / Dutton-Regester, K. / Capatana, A. / Holman, E.C. / Bosenberg, M. / Sznol, M. / Kluger, H.M. / Brash, D.E. / Stern, D.F. / Materin, M.A. / Lo, R.S. / Mane, S. / Ma, S. / Kidd, K.K. / Hayward, N.K. / Lifton, R.P. / Schlessinger, J. / Boggon, T.J. / Halaban, R.
External linksNat. Genet. / PubMed:22842228
MethodsX-ray diffraction
Resolution2.1 - 2.6 Å
Structure data

PDB-3sbd:
Crystal structure of RAC1 P29S mutant
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3sbe:
Crystal structure of RAC1 P29S mutant
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-3th5:
Crystal structure of wild-type RAC1
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Rossmann fold / GTPASE / GTP Binding / SIGNALING PROTEIN / PROTEIN BINDING

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