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Structure paper

TitleThe Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage.
Journal, issue, pagesJ. Mol. Biol., Vol. 424, Page 109-124, Year 2012
Publish dateJun 15, 2012 (structure data deposition date)
AuthorsWendorff, T.J. / Schmidt, B.H. / Heslop, P. / Austin, C.A. / Berger, J.M.
External linksJ. Mol. Biol. / PubMed:22841979
MethodsX-ray diffraction
Resolution2.901 Å
Structure data

PDB-4fm9:
Human topoisomerase II alpha bound to DNA
Method: X-RAY DIFFRACTION / Resolution: 2.901 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsISOMERASE/DNA / TOPOISOMERASE / DNA-BINDING / PROTEIN-DNA COMPLEX / ISOMERASE-DNA COMPLEX

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